TARGETING BCL-6 IN DIFFUSE LARGE B-CELL LYMPHOMA: WHAT DOES THIS MEAN FOR THE FUTURE TREATMENT?

Por Cerchietti, Leandro, Melnick, Ari
Publicado em 2013

Therapeutic implication of concomitant chromosomal aberrations in patients with aggressive B-cell lymphomas

Por Marullo, Rossella, Rutherford, Sarah C., Leonard, John P., Cerchietti, Leandro
Publicado no Cell Cycle (2016)

Effective combination therapies for B cell lymphoma predicted by a virtual disease model

Por Du, Wei, Goldstein, Rebecca, Jiang, Yanwen, Aly, Omar, Cerchietti, Leandro, Melnick, Ari, Elemento, Olivier
Publicado no Cancer Res (2017)

Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer

Por Ghetu, Alexandru F., Corcoran, Connie M., Cerchietti, Leandro, Bardwell, Vivian J., Melnick, Ari, Privé, Gilbert G.
Publicado em 2008

Hsp90 is a viable therapeutic target in the treatment of KSHV-associated primary effusion lymphoma

Por Nayar, Utthara, Lu, Pin, Vider, Jelena, Cerchietti, Leandro, Chiosis, Gabriela, Wang, Lynn, Blasberg, Ronald, Cesarman, Ethel
Publicado em 2010

Microscale Bioadhesive Hydrogel Arrays for Cell Engineering Applications

Por PATEL, RAVI GHANSHYAM, PURWADA, ALBERTO, CERCHIETTI, LEANDRO, INGHIRAMI, GIORGIO, MELNICK, ARI, GAHARWAR, AKHILESH K., SINGH, ANKUR
Publicado em 2014

Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas

Por Polo, Jose M., Juszczynski, Przemyslaw, Monti, Stefano, Cerchietti, Leandro, Ye, Kenny, Greally, John M., Shipp, Margaret, Melnick, Ari
Publicado em 2007

Ex vivo engineered immune organoids for controlled germinal center reactions

Por Purwada, Alberto, Jaiswal, Manish K., Ahn, Haelee, Nojima, Takuya, Kitamura, Daisuke, Gaharwar, Akhilesh K., Cerchietti, Leandro, Singh, Ankur
Publicado no Biomaterials (2015)

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

Por Cerchietti, Leandro C., Yang, Shao Ning, Shaknovich, Rita, Hatzi, Katerina, Polo, Jose M., Chadburn, Amy, Dowdy, Steven F., Melnick, Ari
Publicado em 2009

Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth

Por Izzo, Franco, Mercogliano, Florencia, Venturutti, Leandro, Tkach, Mercedes, Inurrigarro, Gloria, Schillaci, Roxana, Cerchietti, Leandro, Elizalde, Patricia V, Proietti, Cecilia J
Publicado no Breast Cancer Res (2014)

Integrin-specific hydrogels as adaptable tumor organoids for malignant B and T cells

Por Tian, Ye F., Ahn, Haelee, Schneider, Rebecca S., Yang, Shao Ning, Roman-Gonzalez, Lidia, Melnick, Ari M., Cerchietti, Leandro, Singh, Ankur
Publicado no Biomaterials (2015)

DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma

Por Shaknovich, Rita, Geng, Huimin, Johnson, Nathalie A., Tsikitas, Lucas, Cerchietti, Leandro, Greally, John M., Gascoyne, Randy D., Elemento, Olivier, Melnick, Ari
Publicado em 2010

Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma

Por Dupont, Thibault, Yang, ShaoNing, Patel, Jayeshkumar, Hatzi, Katerina, Malik, Alka, Tam, Wayne, Martin, Peter, Leonard, John, Melnick, Ari, Cerchietti, Leandro
Publicado no Oncotarget (2015)

Sequential transcription factor targeting for diffuse large B-cell lymphomas

Por Cerchietti, Leandro C, Polo, Jose M, Da Silva, Gustavo F, Farinha, Pedro, Shaknovich, Rita, Gascoyne, Randy D, Dowdy, Steven F, Melnick, Ari
Publicado em 2008

MiR-592 Regulates the Induction and Cell Death-Promoting Activity of p75(NTR) in Neuronal Ischemic Injury

Por Irmady, Krithi, Jackman, Katherine A., Padow, Victoria A., Shahani, Neelam, Martin, Laura Andres, Cerchietti, Leandro, Unsicker, Klaus, Iadecola, Costantino, Hempstead, Barbara L.
Publicado em 2014

The transcriptional modulator BCL6 as a molecular target for breast cancer therapy

Por Walker, Sarah R., Liu, Suhu, Xiang, Michael, Nicolais, Maria, Hatzi, Katerina, Giannopoulou, Eugenia, Elemento, Olivier, Cerchietti, Leandro, Melnick, Ari, Frank, David A.
Publicado em 2014

Inhibition of Anaplastic Lymphoma Kinase (ALK) Activity Provides a Therapeutic Approach for CLTC-ALK-Positive Human Diffuse Large B Cell Lymphomas

Por Cerchietti, Leandro, Damm-Welk, Christine, Vater, Inga, Klapper, Wolfram, Harder, Lana, Pott, Christiane, Yang, Shao Ning, Reiter, Alfred, Siebert, Reiner, Melnick, Ari, Woessmann, Willi
Publicado em 2011

Pre-B cell receptor–mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC

Por Nahar, Rahul, Ramezani-Rad, Parham, Mossner, Maximilian, Duy, Cihangir, Cerchietti, Leandro, Geng, Huimin, Dovat, Sinisa, Jumaa, Hassan, Ye, B. Hilda, Melnick, Ari, Müschen, Markus
Publicado em 2011

Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes

Por Ruan, Jia, Luo, Min, Wang, Chunjie, Fan, Lei, Yang, Shao Ning, Cardenas, Mariano, Geng, Huimin, Leonard, John P., Melnick, Ari, Cerchietti, Leandro, Hajjar, Katherine A.
Publicado em 2013

Combinatorial epigenetic therapy in diffuse large B cell lymphoma pre-clinical models and patients

Por Pera, Benet, Tang, Tiffany, Marullo, Rossella, Yang, Shao-Ning, Ahn, Haelee, Patel, Jayeshkumar, Elstrom, Rebecca, Ruan, Jia, Furman, Richard, Leonard, John, Cerchietti, Leandro, Martin, Peter
Publicado no Clin Epigenetics (2016)