Inhibition of Anaplastic Lymphoma Kinase (ALK) Activity Provides a Therapeutic Approach for CLTC-ALK-Positive Human Diffuse Large B Cell Lymphomas

ALK positive diffuse large B-cell lymphomas (DLBCL) are a distinct lymphoma subtype associated with a poor outcome. Most of them feature a t(2;17) encoding a clathrin (CLTC)-ALK fusion protein. The contribution of deregulated ALK-activity in the pathogenesis and maintenance of these DLBCLs is not ye...

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Main Authors: Cerchietti, Leandro, Damm-Welk, Christine, Vater, Inga, Klapper, Wolfram, Harder, Lana, Pott, Christiane, Yang, Shao Ning, Reiter, Alfred, Siebert, Reiner, Melnick, Ari, Woessmann, Willi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072987/
https://ncbi.nlm.nih.gov/pubmed/21494621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018436
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