Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas

Diffuse large B cell lymphomas (DLBCLs) often express BCL6, a transcriptional repressor required for the formation of normal germinal centers. In a subset of DLBCLs, BCL6 is deregulated by chromosomal translocations or aberrant somatic hypermutation; in other tumors, BCL6 expression may simply refle...

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Autori principali: Polo, Jose M., Juszczynski, Przemyslaw, Monti, Stefano, Cerchietti, Leandro, Ye, Kenny, Greally, John M., Shipp, Margaret, Melnick, Ari
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805543/
https://ncbi.nlm.nih.gov/pubmed/17360630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611399104
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