BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms

The BCL6 transcriptional repressor is the most commonly involved oncogene in diffuse large B-cell lymphomas (DLBCLs). Constitutive expression of BCL6 mediates lymphomagenesis through aberrant proliferation, survival, and differentiation blockade. Binding of BCL6 to the SMRT/N-CoR corepressors mediat...

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Autori principali: Parekh, Samir, Polo, Jose M., Shaknovich, Rita, Juszczynski, Przemyslaw, Lev, Paola, Ranuncolo, Stella M., Yin, Yingnan, Klein, Ulf, Cattoretti, Giorgio, Favera, Riccardo Dalla, Shipp, Margaret A., Melnick, Ari
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2007
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976344/
https://ncbi.nlm.nih.gov/pubmed/17545502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-069575
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