BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt

Tonic B-cell receptor (BCR) signaling is a key survival pathway during normal B-cell ontogenesis and in a subset of diffuse large B-cell lymphomas (DLBCLs). We previously demonstrated that BCR-dependent DLBCL cell lines and primary tumors underwent apoptosis after treatment with an ATP-competitive i...

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Detalhes bibliográficos
Main Authors: Juszczynski, Przemyslaw, Chen, Linfeng, O'Donnell, Evan, Polo, Jose M., Ranuncolo, Stella M., Dalla-Favera, Riccardo, Melnick, Ari, Shipp, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796136/
https://ncbi.nlm.nih.gov/pubmed/19855081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-204362
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