Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth

INTRODUCTION: The transcription factor GATA3 is involved in mammary gland development and is crucial for the maintenance of the differentiated status of luminal epithelial cells. The role of GATA3 in breast cancer as a tumor suppressor has been established, although insights into the mechanism of GA...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Izzo, Franco, Mercogliano, Florencia, Venturutti, Leandro, Tkach, Mercedes, Inurrigarro, Gloria, Schillaci, Roxana, Cerchietti, Leandro, Elizalde, Patricia V, Proietti, Cecilia J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303201/
https://ncbi.nlm.nih.gov/pubmed/25479686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0491-x
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