Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development

INTRODUCTION: Experimental and clinical evidence points to a critical role of progesterone and the nuclear progesterone receptor (PR) in controlling mammary gland tumorigenesis. However, the molecular mechanisms of progesterone action in breast cancer still remain elusive. On the other hand, micro R...

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Dettagli Bibliografici
Autori principali: Rivas, Martin A, Venturutti, Leandro, Huang, Yi-Wen, Schillaci, Roxana, Huang, Tim Hui-Ming, Elizalde, Patricia V
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446340/
https://ncbi.nlm.nih.gov/pubmed/22583478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3187
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