Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development

INTRODUCTION: Experimental and clinical evidence points to a critical role of progesterone and the nuclear progesterone receptor (PR) in controlling mammary gland tumorigenesis. However, the molecular mechanisms of progesterone action in breast cancer still remain elusive. On the other hand, micro R...

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Main Authors: Rivas, Martin A, Venturutti, Leandro, Huang, Yi-Wen, Schillaci, Roxana, Huang, Tim Hui-Ming, Elizalde, Patricia V
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446340/
https://ncbi.nlm.nih.gov/pubmed/22583478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3187
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