Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis

Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by an increased risk of myeloid malignancies. Exome sequencing of 3 elderly females with clonal hematopoiesis demonstrated by X-inactivation analysis identified somatic TET2 mutations. Recurrence testing found...

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Auteurs principaux: Busque, Lambert, Patel, Jay P., Figueroa, Maria, Vasanthakumar, Aparna, Provost, Sylvie, Hamilou, Zineb, Mollica, Luigina, Li, Juan, Viale, Agnes, Heguy, Adriana, Hassimi, Maryam, Socci, Nicholas, Bhatt, Parva K., Gonen, Mithat, Mason, Christopher E., Melnick, Ari, Godley, Lucy A., Brennan, Cameron, Abdel-Wahab, Omar, Levine, Ross L.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483435/
https://ncbi.nlm.nih.gov/pubmed/23001125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2413
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