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Recurrent Somatic TET2 Mutations in Normal Elderly Individuals With Clonal Hematopoiesis
Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by an increased risk of myeloid malignancies. Exome sequencing of 3 elderly females with clonal hematopoiesis demonstrated by X-inactivation analysis identified somatic TET2 mutations. Recurrence testing found...
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| Główni autorzy: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3483435/ https://ncbi.nlm.nih.gov/pubmed/23001125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2413 |
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