Dnmt3a is essential for hematopoietic stem cell differentiation

Loss of the de novo DNA methyltransferases Dnmt3a and Dnmt3b in embryonic stem cells obstructs differentiation; however, the role of these enzymes in somatic stem cells is largely unknown. Using conditional ablation, we show that Dnmt3a loss progressively impairs hematopoietic stem cell (HSC) differ...

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Detalhes bibliográficos
Main Authors: Challen, Grant A, Sun, Deqiang, Jeong, Mira, Luo, Min, Jelinek, Jaroslav, Berg, Jonathan S, Bock, Christoph, Vasanthakumar, Aparna, Gu, Hongcang, Xi, Yuanxin, Liang, Shoudan, Lu, Yue, Darlington, Gretchen J, Meissner, Alexander, Issa, Jean-Pierre J, Godley, Lucy A, Li, Wei, Goodell, Margaret A
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637952/
https://ncbi.nlm.nih.gov/pubmed/22138693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.1009
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