Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

Somatic mutations in DNMT3A are recurrent events across a range of blood cancers. Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self-renewal at the expense of differentiation. Moreover, DNMT3A mutations can be detected in the blood of aging individuals, indicating...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Jeong, Mira, Park, Hyun Jung, Celik, Hamza, Ostrander, Elizabeth L., Reyes, Jaime M., Guzman, Anna, Rodriguez, Benjamin, Lei, Yong, Lee, Yeojin, Ding, Lei, Guryanova, Olga A., Li, Wei, Goodell, Margaret A., Challen, Grant A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908249/
https://ncbi.nlm.nih.gov/pubmed/29617651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.025
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados