Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness

The DNA methylation regulators DNMT3A and TET2 are recurrently mutated in hematological disorders. Despite possessing antagonistic biochemical activities, loss-of-function murine models show overlapping phenotypes in terms of increased hematopoietic stem cell (HSC) fitness. Here, we directly compare...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Ostrander, Elizabeth L., Kramer, Ashley C., Mallaney, Cates, Celik, Hamza, Koh, Won Kyun, Fairchild, Jake, Haussler, Emily, Zhang, Christine R.C., Challen, Grant A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
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Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160307/
https://ncbi.nlm.nih.gov/pubmed/32220332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.02.011
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