JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells

How specific genetic lesions contribute to transformation of non-malignant myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS) to secondary acute myeloid leukemia (sAML) are poorly understood. JARID2 is lost by chromosomal deletions in a proportion of MPN/MDS cases that progress t...

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Pubblicato in:Cancer Cell
Autori principali: Celik, Hamza, Koh, Won Kyun, Kramer, Ashley C., Ostrander, Elizabeth L., Mallaney, Cates, Fisher, Daniel A.C., Xiang, Jingyu, Wilson, William C., Martens, Andrew, Kothari, Alok, Fishberger, Gregory, Tycksen, Eric, Karpova, Darja, Duncavage, Eric J., Lee, Youngsook, Oh, Stephen T., Challen, Grant A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237100/
https://ncbi.nlm.nih.gov/pubmed/30423295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.008
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