Dnmt3a Regulates T-cell Development and Suppresses T-ALL Transformation

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic neoplasm resulting from the malignant transformation of T-cell progenitors, and comprises approximately 15% and 25% of pediatric and adult ALL cases respectively. It is well-established that activating NOTCH1 mutations are th...

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Vydáno v:Leukemia
Hlavní autoři: Kramer, Ashley C., Kothari, Alok, Wilson, W. Casey, Celik, Hamza, Nikitas, John, Mallaney, Cates, Ostrander, Elizabeth L., Eultgen, Elizabeth, Martens, Andrew, Valentine, Mark C., Young, Andrew L., Druley, Todd E., Figueroa, Maria E., Zhang, Bo, Challen, Grant A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636646/
https://ncbi.nlm.nih.gov/pubmed/28321121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.89
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