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Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with poor prognosis. Past studies in mice revealed Dnmt3a-knockout (KO) hematopoietic stem cells (HSCs) had increased self-renewal, but no leuk...
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| Publicado en: | Blood |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4304108/ https://ncbi.nlm.nih.gov/pubmed/25416277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594648 |
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