Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with poor prognosis. Past studies in mice revealed Dnmt3a-knockout (KO) hematopoietic stem cells (HSCs) had increased self-renewal, but no leuk...

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Publicado en:Blood
Autores principales: Mayle, Allison, Yang, Liubin, Rodriguez, Benjamin, Zhou, Ting, Chang, Edmund, Curry, Choladda V., Challen, Grant A., Li, Wei, Wheeler, David, Rebel, Vivienne I., Goodell, Margaret A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2015
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304108/
https://ncbi.nlm.nih.gov/pubmed/25416277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594648
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