Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with poor prognosis. Past studies in mice revealed Dnmt3a-knockout (KO) hematopoietic stem cells (HSCs) had increased self-renewal, but no leuk...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood
Päätekijät: Mayle, Allison, Yang, Liubin, Rodriguez, Benjamin, Zhou, Ting, Chang, Edmund, Curry, Choladda V., Challen, Grant A., Li, Wei, Wheeler, David, Rebel, Vivienne I., Goodell, Margaret A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2015
Aiheet:
Hematopoiesis and Stem Cells
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304108/
https://ncbi.nlm.nih.gov/pubmed/25416277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594648
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