Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with poor prognosis. Past studies in mice revealed Dnmt3a-knockout (KO) hematopoietic stem cells (HSCs) had increased self-renewal, but no leuk...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Mayle, Allison, Yang, Liubin, Rodriguez, Benjamin, Zhou, Ting, Chang, Edmund, Curry, Choladda V., Challen, Grant A., Li, Wei, Wheeler, David, Rebel, Vivienne I., Goodell, Margaret A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304108/
https://ncbi.nlm.nih.gov/pubmed/25416277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594648
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