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Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with poor prognosis. Past studies in mice revealed Dnmt3a-knockout (KO) hematopoietic stem cells (HSCs) had increased self-renewal, but no leuk...
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| Pubblicato in: | Blood |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4304108/ https://ncbi.nlm.nih.gov/pubmed/25416277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594648 |
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