Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with poor prognosis. Past studies in mice revealed Dnmt3a-knockout (KO) hematopoietic stem cells (HSCs) had increased self-renewal, but no leuk...

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Detalhes bibliográficos
Publicado no:Blood
Principais autores: Mayle, Allison, Yang, Liubin, Rodriguez, Benjamin, Zhou, Ting, Chang, Edmund, Curry, Choladda V., Challen, Grant A., Li, Wei, Wheeler, David, Rebel, Vivienne I., Goodell, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304108/
https://ncbi.nlm.nih.gov/pubmed/25416277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-594648
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