DNMT3A loss drives enhancer hypomethylation in FLT3-ITD-associated leukemias

DNMT3A, the gene encoding the de novo DNA methyltransferase 3A, is among the most frequently mutated genes in hematologic malignancies. However, the mechanisms through which DNMT3A normally suppresses malignancy development are unknown. Here, we show that DNMT3A loss synergizes with the FLT3 interna...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Yang, Liubin, Rodriguez, Benjamin, Mayle, Allison, Park, Hyun Jung, Lin, Xueqiu, Luo, Min, Jeong, Mira, Curry, Choladda V., Kim, Sang-Bae, Ruau, David, Zhang, Xiaotian, Zhou, Ting, Zhou, Michael, Rebel, Vivienne I., Challen, Grant A., Gottgens, Berthold, Lee, Ju-Seog, Rau, Rachel, Li, Wei, Goodell, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908977/
https://ncbi.nlm.nih.gov/pubmed/27300438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.05.003
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados