DNMT3A loss drives enhancer hypomethylation in FLT3-ITD-associated leukemias

DNMT3A, the gene encoding the de novo DNA methyltransferase 3A, is among the most frequently mutated genes in hematologic malignancies. However, the mechanisms through which DNMT3A normally suppresses malignancy development are unknown. Here, we show that DNMT3A loss synergizes with the FLT3 interna...

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Vydáno v:Cancer Cell
Hlavní autoři: Yang, Liubin, Rodriguez, Benjamin, Mayle, Allison, Park, Hyun Jung, Lin, Xueqiu, Luo, Min, Jeong, Mira, Curry, Choladda V., Kim, Sang-Bae, Ruau, David, Zhang, Xiaotian, Zhou, Ting, Zhou, Michael, Rebel, Vivienne I., Challen, Grant A., Gottgens, Berthold, Lee, Ju-Seog, Rau, Rachel, Li, Wei, Goodell, Margaret A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908977/
https://ncbi.nlm.nih.gov/pubmed/27300438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.05.003
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