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Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model
Internal tandem duplications of the juxtamembrane domain of FLT3 (FLT3/ITD) are among the most common mutations in Acute Myeloid Leukemia (AML). Resulting in constitutive activation of the kinase, FLT3/ITD portends a particularly poor prognosis, with reduced overall survival and increased rates of r...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5342464/ https://ncbi.nlm.nih.gov/pubmed/27636998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11986 |
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