Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

TET2 converts 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) in DNA and is frequently mutated in myeloid malignancies, including myeloproliferative neoplasms. Here we show that the level of 5-hmC is decreased in granulocyte DNA from myeloproliferative neoplasm patients with TET2 mutations compa...

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Main Authors: Pronier, Elodie, Almire, Carole, Mokrani, Hayat, Vasanthakumar, Aparna, Simon, Audrey, da Costa Reis Monte Mor, Barbara, Massé, Aline, Le Couédic, Jean-Pierre, Pendino, Frédéric, Carbonne, Bruno, Larghero, Jérôme, Ravanat, Jean-Luc, Casadevall, Nicole, Bernard, Olivier A., Droin, Nathalie, Solary, Eric, Godley, Lucy A., Vainchenker, William, Plo, Isabelle, Delhommeau, François
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292425/
https://ncbi.nlm.nih.gov/pubmed/21734233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324707
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