Targeting acute myeloid leukemia stem cells: a review and principles for the development of clinical trials

Por Pollyea, Daniel A., Gutman, Jonathan A., Gore, Lia, Smith, Clayton A., Jordan, Craig T.
Publicado em 2014

Reactive Oxygen Species Regulate Nucleostemin Oligomerization and Protein Degradation

Por Huang, Min, Whang, Patrick, Chodaparambil, Jayanth V., Pollyea, Daniel A., Kusler, Brenda, Xu, Liwen, Felsher, Dean W., Mitchell, Beverly S.
Publicado em 2011

Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia

Por Gardner, Lori A., Klawitter, Jelena, Gregory, Mark A., Zaberezhnyy, Vadym, Baturin, Dmitry, Pollyea, Daniel A., Takebe, Naoko, Christians, Uwe, Gore, Lia, DeGregori, James, Porter, Christopher C.
Publicado em 2014

2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine level...

Por Pollyea, Daniel A., Kohrt, Holbrook E., Zhang, Bing, Zehnder, James, Schenkein, David, Fantin, Valeria, Straley, Kimberly, Vasanthakumar, Aparna, Abdel-Wahab, Omar, Levine, Ross, Godley, Lucy A., Medeiros, Bruno C.
Publicado em 2012

Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia

Por Pollyea, Daniel A., Zehnder, James, Coutre, Steve, Gotlib, Jason R., Gallegos, Leonel, Abdel-Wahab, Omar, Greenberg, Peter, Zhang, Bing, Liedtke, Michaela, Berube, Caroline, Levine, Ross, Mitchell, Beverly S., Medeiros, Bruno C.
Publicado em 2013

Clonality of neutrophilia associated with plasma cell neoplasms: report of a SETBP1 mutation and analysis of a single institution series

Por Stevens, Brett, Maxson, Julia, Tyner, Jeffrey, Smith, Clayton A., Gutman, Jonathan A., Robinson, William, Jordan, Craig T., Lee, Choon-Kee, Swisshelm, Karen, Tobin, Jennifer, Wei, Qi, Schowinsky, Jeffrey, Rinella, Sean, Lee, Hea Gie, Pollyea, Daniel A.
Publicado no Leuk Lymphoma (2015)

MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia

Por Riedel, Simone S., Haladyna, Jessica N., Bezzant, Matthew, Stevens, Brett, Pollyea, Daniel A., Sinha, Amit U., Armstrong, Scott A., Wei, Qi, Pollock, Roy M., Daigle, Scott R., Jordan, Craig T., Ernst, Patricia, Neff, Tobias, Bernt, Kathrin M.
Publicado no J Clin Invest (2016)

Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations

Por Alvarez-Calderon, Francesca, Gregory, Mark A., Pham-Danis, Catherine, DeRyckere, Deborah, Stevens, Brett M., Zaberezhnyy, Vadym, Hill, Amanda A., Gemta, Lelisa, Kumar, Amit, Kumar, Vijay, Wempe, Michael F., Pollyea, Daniel A., Jordan, Craig T., Serkova, Natalie J., Graham, Douglas K., DeGregori, James
Publicado no Clin Cancer Res (2014)

Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells

Por Pei, Shanshan, Minhajuddin, Mohammad, D'Alessandro, Angelo, Nemkov, Travis, Stevens, Brett M., Adane, Biniam, Khan, Nabilah, Hagen, Fred K., Yadav, Vinod K., De, Subhajyoti, Ashton, John M., Hansen, Kirk C., Gutman, Jonathan A., Pollyea, Daniel A., Crooks, Peter A., Smith, Clayton, Jordan, Craig T.
Publicado no J Biol Chem (2016)

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia

Por Gregory, Mark A., D’Alessandro, Angelo, Alvarez-Calderon, Francesca, Kim, Jihye, Nemkov, Travis, Adane, Biniam, Rozhok, Andrii I., Kumar, Amit, Kumar, Vijay, Pollyea, Daniel A., Wempe, Michael F., Jordan, Craig T., Serkova, Natalie J., Tan, Aik Choon, Hansen, Kirk C., DeGregori, James
Publicado no Proc Natl Acad Sci U S A (2016)

Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells.

Por Pei, Shanshan, Minhajuddin, Mohammad, D'Alessandro, Angelo, Nemkov, Travis, Stevens, Brett M., Adane, Biniam, Khan, Nabilah, Hagen, Fred K., Yadav, Vinod K., De, Subhajyoti, Ashton, John M., Hansen, Kirk C., Gutman, Jonathan A., Pollyea, Daniel A., Crooks, Peter A., Smith, Clayton, Jordan, Craig T.
Publicado no J Biol Chem (2016)

Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study

Por Steensma, David P., Abedi, Medrdad, Bejar, Rafael, Cogle, Christopher R., Foucar, Kathryn, Garcia-Manero, Guillermo, George, Tracy I., Grinblatt, David, Komrokji, Rami, Ma, Xiaomei, Maciejewski, Jaroslaw, Pollyea, Daniel A., Savona, Michael R., Scott, Bart, Sekeres, Mikkael A., Thompson, Michael A., Swern, Arlene S., Nifenecker, Melissa, Sugrue, Mary M., Erba, Harry
Publicado no BMC Cancer (2016)

Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML

Por Maxson, Julia E., Gotlib, Jason, Pollyea, Daniel A., Fleischman, Angela G., Agarwal, Anupriya, Eide, Christopher A., Bottomly, Daniel, Wilmot, Beth, McWeeney, Shannon K., Tognon, Cristina E., Pond, J. Blake, Collins, Robert H., Goueli, Basem, Oh, Stephen T., Deininger, Michael W., Chang, Bill H., Loriaux, Marc M., Druker, Brian J., Tyner, Jeffrey W.
Publicado em 2013

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

Por Koo, Gi-Bang, Morgan, Michael J, Lee, Da-Gyum, Kim, Woo-Jung, Yoon, Jung-Ho, Koo, Ja Seung, Kim, Seung Il, Kim, Soo Jung, Son, Mi Kwon, Hong, Soon Sun, Levy, Jean M Mulcahy, Pollyea, Daniel A, Jordan, Craig T, Yan, Pearlly, Frankhouser, David, Nicolet, Deedra, Maharry, Kati, Marcucci, Guido, Choi, Kyeong Sook, Cho, Hyeseong, Thorburn, Andrew, Kim, You-Sun
Publicado no Cell Res (2015)

Myelodysplastic Syndromes, Version 2.2015: Featured Updates to the NCCN Guidelines

Por Greenberg, Peter L., Stone, Richard M., Bejar, Rafael, Bennett, John M., Bloomfield, Clara D., Borate, Uma, De Castro, Carlos M., Deeg, H. Joachim, DeZern, Amy E., Fathi, Amir T., Frankfurt, Olga, Gaensler, Karin, Garcia-Manero, Guillermo, Griffiths, Elizabeth A., Head, David, Klimek, Virginia, Komrokji, Rami, Kujawski, Lisa A., Maness, Lori J., O’Donnell, Margaret R., Pollyea, Daniel A., Scott, Bart, Shami, Paul J., Stein, Brady L., Westervelt, Peter, Wheeler, Benton, Shead, Dorothy A., Smith, Courtney
Publicado no J Natl Compr Canc Netw (2015)

Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies

Por Lewinsohn, Maya, Brown, Anna L., Weinel, Luke M., Phung, Connie, Rafidi, George, Lee, Ming K., Schreiber, Andreas W., Feng, Jinghua, Babic, Milena, Chong, Chan-Eng, Lee, Young, Yong, Agnes, Suthers, Graeme K., Poplawski, Nicola, Altree, Meryl, Phillips, Kerry, Jaensch, Louise, Fine, Miriam, D’Andrea, Richard J., Lewis, Ian D., Medeiros, Bruno C., Pollyea, Daniel A., King, Mary-Claire, Walsh, Tom, Keel, Siobán, Shimamura, Akiko, Godley, Lucy A., Hahn, Christopher N., Churpek, Jane E., Scott, Hamish S.
Publicado no Blood (2016)