Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells

Although multidrug approaches to cancer therapy are common, few strategies are based on rigorous scientific principles. Rather, drug combinations are largely dictated by empirical or clinical parameters. In the present study we developed a strategy for rational design of a regimen that selectively t...

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Foilsithe in:J Biol Chem
Main Authors: Pei, Shanshan, Minhajuddin, Mohammad, D'Alessandro, Angelo, Nemkov, Travis, Stevens, Brett M., Adane, Biniam, Khan, Nabilah, Hagen, Fred K., Yadav, Vinod K., De, Subhajyoti, Ashton, John M., Hansen, Kirk C., Gutman, Jonathan A., Pollyea, Daniel A., Crooks, Peter A., Smith, Clayton, Jordan, Craig T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Molecular Bases of Disease
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063982/
https://ncbi.nlm.nih.gov/pubmed/27573247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750653
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