Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells

Although multidrug approaches to cancer therapy are common, few strategies are based on rigorous scientific principles. Rather, drug combinations are largely dictated by empirical or clinical parameters. In the present study we developed a strategy for rational design of a regimen that selectively t...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Pei, Shanshan, Minhajuddin, Mohammad, D'Alessandro, Angelo, Nemkov, Travis, Stevens, Brett M., Adane, Biniam, Khan, Nabilah, Hagen, Fred K., Yadav, Vinod K., De, Subhajyoti, Ashton, John M., Hansen, Kirk C., Gutman, Jonathan A., Pollyea, Daniel A., Crooks, Peter A., Smith, Clayton, Jordan, Craig T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063982/
https://ncbi.nlm.nih.gov/pubmed/27573247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750653
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