An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells

Leukemia stem cells (LSCs) are thought to play a central role in the pathogenesis of acute leukemia and likely contribute to both disease initiation and relapse. Therefore, identification of agents that target LSCs is an important consideration for the development of new therapies. To this end, we h...

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Hlavní autoři: Guzman, Monica L., Rossi, Randall M., Neelakantan, Sundar, Li, Xiaojie, Corbett, Cheryl A., Hassane, Duane C., Becker, Michael W., Bennett, John M., Sullivan, Edmund, Lachowicz, Joshua L., Vaughan, Andrew, Sweeney, Christopher J., Matthews, William, Carroll, Martin, Liesveld, Jane L., Crooks, Peter A., Jordan, Craig T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234793/
https://ncbi.nlm.nih.gov/pubmed/17804695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-090621
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