Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino acid uptake, steady-state levels, and catabolism are all elevated in the leukemia stem cell (LSC) population. Furtherm...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Jones, Courtney L., Stevens, Brett M., D'Alessandro, Angelo, Reisz, Julie A., Culp-Hill, Rachel, Nemkov, Travis, Pei, Shanshan, Khan, Nabilah, Adane, Biniam, Ye, Haobin, Krug, Anna, Reinhold, Dominik, Smith, Clayton, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280965/
https://ncbi.nlm.nih.gov/pubmed/30423294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.005
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