Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells

We previously demonstrated that leukemia stem cells (LSCs) in de novo acute myeloid leukemia (AML) patients are selectively reliant on amino acid metabolism and that treatment with the combination of venetoclax and azacitidine (ven/aza) inhibits amino acid metabolism, leading to cell death. In contr...

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Publicado no:Cell Stem Cell
Main Authors: Jones, Courtney L., Stevens, Brett M., Pollyea, Daniel A., Culp-Hill, Rachel, Reisz, Julie A., Nemkov, Travis, Gehrke, Sarah, Gamboni, Fabia, Krug, Anna, Winters, Amanda, Pei, Shanshan, Gustafson, Annika, Ye, Haobin, Inguva, Anagha, Amaya, Maria, Minhajuddin, Mohammad, Abbott, Diana, Becker, Michael W., DeGregori, James, Smith, Clayton, D'Alessandro, Angelo, Jordan, Craig T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655603/
https://ncbi.nlm.nih.gov/pubmed/32822582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.07.021
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