Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

We have previously demonstrated that oxidative phosphorylation is required for the survival of human leukemia stem cells (LSCs) from patients with acute myeloid leukemia (AML). More recently, we demonstrated that LSCs in patients with de novo AML rely on amino acid metabolism to drive oxidative phos...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Jones, Courtney L., Stevens, Brett M., D’Alessandro, Angelo, Culp-Hill, Rachel, Reisz, Julie A., Pei, Shanshan, Gustafson, Annika, Khan, Nabilah, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2019
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659257/
https://ncbi.nlm.nih.gov/pubmed/31101624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019898114
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