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Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

We have previously demonstrated that oxidative phosphorylation is required for the survival of human leukemia stem cells (LSCs) from patients with acute myeloid leukemia (AML). More recently, we demonstrated that LSCs in patients with de novo AML rely on amino acid metabolism to drive oxidative phos...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Jones, Courtney L., Stevens, Brett M., D’Alessandro, Angelo, Culp-Hill, Rachel, Reisz, Julie A., Pei, Shanshan, Gustafson, Annika, Khan, Nabilah, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6659257/
https://ncbi.nlm.nih.gov/pubmed/31101624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019898114
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