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Reactive Oxygen Species Regulate Nucleostemin Oligomerization and Protein Degradation
Nucleostemin (NS) is a nucleolar-nucleoplasmic shuttle protein that regulates cell proliferation, binds p53 and Mdm2, and is highly expressed in tumor cells. We have identified NS as a target of oxidative regulation in transformed hematopoietic cells. NS oligomerization occurs in HL-60 leukemic cell...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064158/ https://ncbi.nlm.nih.gov/pubmed/21242306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.208470 |
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