Reactive Oxygen Species Regulate Nucleostemin Oligomerization and Protein Degradation

Nucleostemin (NS) is a nucleolar-nucleoplasmic shuttle protein that regulates cell proliferation, binds p53 and Mdm2, and is highly expressed in tumor cells. We have identified NS as a target of oxidative regulation in transformed hematopoietic cells. NS oligomerization occurs in HL-60 leukemic cell...

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Hlavní autoři: Huang, Min, Whang, Patrick, Chodaparambil, Jayanth V., Pollyea, Daniel A., Kusler, Brenda, Xu, Liwen, Felsher, Dean W., Mitchell, Beverly S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064158/
https://ncbi.nlm.nih.gov/pubmed/21242306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.208470
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