ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia

Activating mutations in FMS-like tyrosine kinase 3 (FLT3) are common in acute myeloid leukemia (AML) and drive leukemic cell growth and survival. Although FLT3 inhibitors have shown considerable promise for the treatment of AML, they ultimately fail to achieve long-term remissions as monotherapy. To...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Gregory, Mark A., D’Alessandro, Angelo, Alvarez-Calderon, Francesca, Kim, Jihye, Nemkov, Travis, Adane, Biniam, Rozhok, Andrii I., Kumar, Amit, Kumar, Vijay, Pollyea, Daniel A., Wempe, Michael F., Jordan, Craig T., Serkova, Natalie J., Tan, Aik Choon, Hansen, Kirk C., DeGregori, James
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2016
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086999/
https://ncbi.nlm.nih.gov/pubmed/27791036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603876113
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