ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia

Activating mutations in FMS-like tyrosine kinase 3 (FLT3) are common in acute myeloid leukemia (AML) and drive leukemic cell growth and survival. Although FLT3 inhibitors have shown considerable promise for the treatment of AML, they ultimately fail to achieve long-term remissions as monotherapy. To...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Gregory, Mark A., D’Alessandro, Angelo, Alvarez-Calderon, Francesca, Kim, Jihye, Nemkov, Travis, Adane, Biniam, Rozhok, Andrii I., Kumar, Amit, Kumar, Vijay, Pollyea, Daniel A., Wempe, Michael F., Jordan, Craig T., Serkova, Natalie J., Tan, Aik Choon, Hansen, Kirk C., DeGregori, James
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
PNAS Plus
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086999/
https://ncbi.nlm.nih.gov/pubmed/27791036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603876113
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