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Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia

Acute myeloid leukemia (AML) is a blood cancer that is poorly responsive to conventional cytotoxic chemotherapy and a diagnosis of AML is usually fatal. More effective and better-tolerated therapies for AML are desperately needed. Activating mutations in FMS-like tyrosine kinase 3 (FLT3) are one of...

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Détails bibliographiques
Publié dans:Exp Hematol
Auteurs principaux: Gregory, Mark A., Nemkov, Travis, Reisz, Julie A., Zaberezhnyy, Vadym, Hansen, Kirk C., D’Alessandro, Angelo, DeGregori, James
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815916/
https://ncbi.nlm.nih.gov/pubmed/28947392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2017.09.007
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