Evidence That Phosphorylation of Iron Regulatory Protein 1 at Serine 138 Destabilizes the [4Fe-4S] Cluster in Cytosolic Aconitase by Enhancing 4Fe-3Fe Cycling

Iron-sulfur cluster-dependent interconversion of iron regulatory protein 1 (IRP1) between its RNA binding and cytosolic aconitase (c-acon) forms controls vertebrate iron homeostasis. Cluster removal from c-acon is thought to include oxidative demetallation as a required step, but little else is unde...

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Auteurs principaux: Deck, Kathryn M., Vasanthakumar, Aparna, Anderson, Sheila A., Goforth, Jeremy B., Kennedy, M. Claire, Antholine, William E., Eisenstein, Richard S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Protein Synthesis, Post-Translational Modification, and Degradation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675999/
https://ncbi.nlm.nih.gov/pubmed/19269970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807717200
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