Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice

BRCA1 is critical for maintenance of genomic stability and interacts directly with several proteins that regulate hematopoietic stem cell function and are part of the Fanconi anemia (FA) double-strand break DNA repair pathway. The effects of complete BRCA1 deficiency on bone marrow (BM) function are...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Vasanthakumar, Aparna, Arnovitz, Stephen, Marquez, Rafael, Lepore, Janet, Rafidi, George, Asom, Anase, Weatherly, Madison, Davis, Elizabeth M., Neistadt, Barbara, Duszynski, Robert, Vardiman, James W., Le Beau, Michelle M., Godley, Lucy A., Churpek, Jane E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722284/
https://ncbi.nlm.nih.gov/pubmed/26644450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-03-635599
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