Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia

TET2 enzymatically converts 5-methyl-cytosine to 5-hydroxymethyl-cytosine, possibly leading to loss of DNA methylation. TET2 mutations are common in myeloid leukemia and were proposed to contribute to leukemogenesis through DNA methylation. To expand on this concept, we studied chronic myelomonocyti...

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Detalhes bibliográficos
Main Authors: Yamazaki, Jumpei, Taby, Rodolphe, Vasanthakumar, Aparna, Macrae, Trisha, Ostler, Kelly R, Shen, Lanlan, Kantarjian, Hagop M, Estecio, Marcos R, Jelinek, Jaroslav, Godley, Lucy A, Issa, Jean-Pierre J
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335912/
https://ncbi.nlm.nih.gov/pubmed/22395470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.7.2.19015
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