Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse

DNA methylation of CpG islands around gene transcription start sites results in gene silencing and plays a role in leukemia pathophysiology. Its impact in leukemia progression is not fully understood. We performed genomewide screening for methylated CpG islands and identified 8 genes frequently meth...

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Hlavní autoři: Kroeger, Heike, Jelinek, Jaroslav, Estécio, Marcos R. H., He, Rong, Kondo, Kimie, Chung, Woonbok, Zhang, Li, Shen, Lanlan, Kantarjian, Hagop M., Bueso-Ramos, Carlos E., Issa, Jean-Pierre J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515110/
https://ncbi.nlm.nih.gov/pubmed/18523155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-126227
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