Aberrant DNA Methylation Is Associated with Disease Progression, Resistance to Imatinib and Shortened Survival in Chronic Myelogenous Leukemia

The epigenetic impact of DNA methylation in chronic myelogenous leukemia (CML) is not completely understood. To elucidate its role we analyzed 120 patients with CML for methylation of promoter-associated CpG islands of 10 genes. Five genes were identified by DNA methylation screening in the K562 cel...

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Main Authors: Jelinek, Jaroslav, Gharibyan, Vazganush, Estecio, Marcos R. H., Kondo, Kimie, He, Rong, Chung, Woonbok, Lu, Yue, Zhang, Nianxiang, Liang, Shoudan, Kantarjian, Hagop M., Cortes, Jorge E., Issa, Jean-Pierre J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132778/
https://ncbi.nlm.nih.gov/pubmed/21760961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022110
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