Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia

TET2 enzymatically converts 5-methyl-cytosine to 5-hydroxymethyl-cytosine, possibly leading to loss of DNA methylation. TET2 mutations are common in myeloid leukemia and were proposed to contribute to leukemogenesis through DNA methylation. To expand on this concept, we studied chronic myelomonocyti...

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Bibliographic Details
Main Authors: Yamazaki, Jumpei, Taby, Rodolphe, Vasanthakumar, Aparna, Macrae, Trisha, Ostler, Kelly R, Shen, Lanlan, Kantarjian, Hagop M, Estecio, Marcos R, Jelinek, Jaroslav, Godley, Lucy A, Issa, Jean-Pierre J
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335912/
https://ncbi.nlm.nih.gov/pubmed/22395470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.7.2.19015
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