TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells

TET1 is a 5-methylcytosine dioxygenase and its DNA demethylating activity has been implicated in pluripotency and reprogramming. However, the precise role of TET1 in DNA methylation regulation outside of developmental reprogramming is still unclear. Here, we show that overexpression of the TET1 cata...

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Bibliografiske detaljer
Main Authors: Jin, Chunlei, Lu, Yue, Jelinek, Jaroslav, Liang, Shoudan, Estecio, Marcos R.H., Barton, Michelle Craig, Issa, Jean-Pierre J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066785/
https://ncbi.nlm.nih.gov/pubmed/24875481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku372
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