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A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer
TET1 oxidizes methylated cytosine into 5-hydroxymethylcytosine (5hmC), resulting in regulation of DNA methylation and gene expression. Full length TET1 (TET1(FL)) has a CXXC domain that binds to unmethylated CpG islands (CGIs). This CXXC domain allows TET1 to protect CGIs from aberrant methylation,...
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5737541/ https://ncbi.nlm.nih.gov/pubmed/28531272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx435 |
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