A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer

TET1 oxidizes methylated cytosine into 5-hydroxymethylcytosine (5hmC), resulting in regulation of DNA methylation and gene expression. Full length TET1 (TET1(FL)) has a CXXC domain that binds to unmethylated CpG islands (CGIs). This CXXC domain allows TET1 to protect CGIs from aberrant methylation,...

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Pubblicato in:Nucleic Acids Res
Autori principali: Good, Charly R., Madzo, Jozef, Patel, Bela, Maegawa, Shinji, Engel, Nora, Jelinek, Jaroslav, Issa, Jean-Pierre J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737541/
https://ncbi.nlm.nih.gov/pubmed/28531272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx435
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