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TET1-mediated hypomethylation activates oncogenic signaling in triple-negative breast cancer

Both gains and losses of DNA methylation are common in cancer, but the factors controlling this balance of methylation remain unclear. Triple-negative breast cancer (TNBC), a subtype that does not overexpress hormone receptors or HER2/NEU, is one of the most hypomethylated cancers observed. Here we...

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Dettagli Bibliografici
Pubblicato in:Cancer Res
Autori principali: Good, Charly Ryan, Panjarian, Shoghag, Kelly, Andrew D., Madzo, Jozef, Patel, Bela, Jelinek, Jaroslav, Issa, Jean-Pierre J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072603/
https://ncbi.nlm.nih.gov/pubmed/29891505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2082
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