Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

Patients with myeloproliferative neoplasms (MPNs) are at significant, cumulative risk of leukemic transformation to acute myeloid leukemia (AML), which is associated with adverse clinical outcome and resistance to standard AML therapies. We performed genomic profiling of post-MPN AML samples; these...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rampal, Raajit, Ahn, Jihae, Abdel-Wahab, Omar, Nahas, Michelle, Wang, Kai, Lipson, Doron, Otto, Geoff A., Yelensky, Roman, Hricik, Todd, McKenney, Anna Sophia, Chiosis, Gabriela, Chung, Young Rock, Pandey, Suveg, van den Brink, Marcel R. M., Armstrong, Scott A., Dogan, Ahmet, Intlekofer, Andrew, Manshouri, Taghi, Park, Christopher Y., Verstovsek, Srdan, Rapaport, Franck, Stephens, Philip J., Miller, Vincent A., Levine, Ross L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273376/
https://ncbi.nlm.nih.gov/pubmed/25516983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407792111
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