Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

Patients with myeloproliferative neoplasms (MPNs) are at significant, cumulative risk of leukemic transformation to acute myeloid leukemia (AML), which is associated with adverse clinical outcome and resistance to standard AML therapies. We performed genomic profiling of post-MPN AML samples; these...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Rampal, Raajit, Ahn, Jihae, Abdel-Wahab, Omar, Nahas, Michelle, Wang, Kai, Lipson, Doron, Otto, Geoff A., Yelensky, Roman, Hricik, Todd, McKenney, Anna Sophia, Chiosis, Gabriela, Chung, Young Rock, Pandey, Suveg, van den Brink, Marcel R. M., Armstrong, Scott A., Dogan, Ahmet, Intlekofer, Andrew, Manshouri, Taghi, Park, Christopher Y., Verstovsek, Srdan, Rapaport, Franck, Stephens, Philip J., Miller, Vincent A., Levine, Ross L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273376/
https://ncbi.nlm.nih.gov/pubmed/25516983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407792111
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