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Genetic analysis of leukemic transformation of chronic myeloproliferative neoplasms

The genetic events which contribute to transformation of myeloproliferative neoplasms (MPN) to acute myeloid leukemia (AML) are not well characterized. We investigated the role of JAK2, TET2, ASXL1, and IDH1 mutations in leukemic transformation of MPNs through mutational analysis of 63 patients with...

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Detalhes bibliográficos
Main Authors: Abdel-Wahab, Omar, Manshouri, Taghi, Patel, Jay, Harris, Kelly, Yao, JinJuan, Hedvat, Cyrus, Heguy, Adriana, Bueso-Ramos, Carlos, Kantarjian, Hagop, Levine, Ross L., Verstovsek, Srdan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947340/
https://ncbi.nlm.nih.gov/pubmed/20068184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3783
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