Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

Patients with myeloproliferative neoplasms (MPNs) are at significant, cumulative risk of leukemic transformation to acute myeloid leukemia (AML), which is associated with adverse clinical outcome and resistance to standard AML therapies. We performed genomic profiling of post-MPN AML samples; these...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Rampal, Raajit, Ahn, Jihae, Abdel-Wahab, Omar, Nahas, Michelle, Wang, Kai, Lipson, Doron, Otto, Geoff A., Yelensky, Roman, Hricik, Todd, McKenney, Anna Sophia, Chiosis, Gabriela, Chung, Young Rock, Pandey, Suveg, van den Brink, Marcel R. M., Armstrong, Scott A., Dogan, Ahmet, Intlekofer, Andrew, Manshouri, Taghi, Park, Christopher Y., Verstovsek, Srdan, Rapaport, Franck, Stephens, Philip J., Miller, Vincent A., Levine, Ross L.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2014
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273376/
https://ncbi.nlm.nih.gov/pubmed/25516983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407792111
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