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Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in one of two tumor suppressor genes, TSC1 and TSC2. Here, we show that absence of Drosophila Tsc1/2 leads to constitutive dS6K activation and inhibition of dPKB, the latter effect being relieved by loss of dS6K. In contrast,...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC187466/ https://ncbi.nlm.nih.gov/pubmed/12381661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.239102 |
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