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Synthesis and evaluation of (18)F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression

Type II topoisomerase (Topo-II) is an ATP-dependent enzyme that is essential in the transcription, replication, and chromosome segregation processes and, as such, represents an attractive target for cancer therapy. Numerous studies indicate that the response to treatment with Topo-II inhibitors is h...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Daumar, Pierre, Zeglis, Brian M., Ramos, Nicholas, Divilov, Vadim, Sevak, Kuntal Kumar, Pillarsetty, NagaVaraKishore, Lewis, Jason S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406421/
https://ncbi.nlm.nih.gov/pubmed/25240701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.09.019
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