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Synthesis and evaluation of (18)F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression

Type II topoisomerase (Topo-II) is an ATP-dependent enzyme that is essential in the transcription, replication, and chromosome segregation processes and, as such, represents an attractive target for cancer therapy. Numerous studies indicate that the response to treatment with Topo-II inhibitors is h...

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Enregistré dans:
Détails bibliographiques
Publié dans:Eur J Med Chem
Auteurs principaux: Daumar, Pierre, Zeglis, Brian M., Ramos, Nicholas, Divilov, Vadim, Sevak, Kuntal Kumar, Pillarsetty, NagaVaraKishore, Lewis, Jason S.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406421/
https://ncbi.nlm.nih.gov/pubmed/25240701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.09.019
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