Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus

Por Chursov, Andrey, Kopetzky, Sebastian J., Leshchiner, Ignaty, Kondofersky, Ivan, Theis, Fabian J., Frishman, Dmitrij, Shneider, Alexander
Publicado em 2012

Comprehensive assessment of cancer missense mutation clustering in protein structures

Por Kamburov, Atanas, Lawrence, Michael S., Polak, Paz, Leshchiner, Ignaty, Lage, Kasper, Golub, Todd R., Lander, Eric S., Getz, Gad
Publicado no Proc Natl Acad Sci U S A (2015)

Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish

Por Ryan, Sean, Willer, Jason, Marjoram, Lindsay, Bagwell, Jennifer, Mankiewicz, Jamie, Leshchiner, Ignaty, Goessling, Wolfram, Bagnat, Michel, Katsanis, Nicholas
Publicado em 2013

A combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery

Por Mahon, Kerry P., Love, Kevin T., Whitehead, Kathryn A., Qin, June, Akinc, Akin, Leshchiner, Elizaveta, Leshchiner, Ignaty, Langer, Robert, Anderson, Daniel G.
Publicado em 2010

Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans

Por Lee, Vivian S., Halabi, Carmen M., Hoffman, Erin P., Carmichael, Nikkola, Leshchiner, Ignaty, Lian, Christine G., Bierhals, Andrew J., Vuzman, Dana, Mecham, Robert P., Frank, Natasha Y., Stitziel, Nathan O.
Publicado no Proc Natl Acad Sci U S A (2016)

An argument for early genomic sequencing in atypical cases: a WISP3 variant leads to diagnosis of progressive pseudorheumatoid arthropathy of childhood

Por Cassa, Christopher A., Smith, Stacy E., Docken, William, Hoffman, Erin, McLaughlin, Heather, Chun, Sung, Leshchiner, Ignaty, Miraoui, Hichem, Raychaudhuri, Soumya, Frank, Natasha Y., Wilson, Brian J., Sunyaev, Shamil R., Maas, Richard L., Vuzman, Dana
Publicado no Rheumatology (Oxford) (2016)

Inherited CHST11/MIR3922 deletion is associated with a novel recessive syndrome presenting with skeletal malformation and malignant lymphoproliferative disease

Por Chopra, Sameer S, Leshchiner, Ignaty, Duzkale, Hatice, McLaughlin, Heather, Giovanni, Monica, Zhang, Chengsheng, Stitziel, Nathan, Fingeroth, Joyce, Joyce, Robin M, Lebo, Matthew, Rehm, Heidi, Vuzman, Dana, Maas, Richard, Sunyaev, Shamil R, Murray, Michael, Cassa, Christopher A
Publicado no Mol Genet Genomic Med (2015)

Mutation mapping and identification by whole-genome sequencing

Por Leshchiner, Ignaty, Alexa, Kristen, Kelsey, Peter, Adzhubei, Ivan, Austin-Tse, Christina A., Cooney, Jeffrey D., Anderson, Heidi, King, Matthew J., Stottmann, Rolf W., Garnaas, Maija K., Ha, Seungshin, Drummond, Iain A., Paw, Barry H., North, Trista E., Beier, David R., Goessling, Wolfram, Sunyaev, Shamil R.
Publicado em 2012

Paired Exome Analysis of Barrett’s Esophagus and Adenocarcinoma

Por Stachler, Matthew D., Taylor-Weiner, Amaro, Peng, Shouyong, McKenna, Aaron, Agoston, Agoston T., Odze, Robert D., Davison, Jon M., Nason, Katie S., Loda, Massimo, Leshchiner, Ignaty, Stewart, Chip, Stojanov, Petar, Seepo, Sara, Lawrence, Michael S., Ferrer-Torres, Daysha, Lin, Jules, Chang, Andrew C., Gabriel, Stacey B., Lander, Eric S., Beer, David G., Getz, Gad, Carter, Scott L., Bass, Adam J.
Publicado no Nat Genet (2015)

Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F

Por Shaw, Alice T., Friboulet, Luc, Leshchiner, Ignaty, Gainor, Justin F., Bergqvist, Simon, Brooun, Alexei, Burke, Benjamin J., Deng, Ya-Li, Liu, Wei, Dardaei, Leila, Frias, Rosa L., Schultz, Kate R., Logan, Jennifer, James, Leonard P., Smeal, Tod, Timofeevski, Sergei, Katayama, Ryohei, Iafrate, A. John, Le, Long, McTigue, Michele, Getz, Gad, Johnson, Ted W., Engelman, Jeffrey A.
Publicado no N Engl J Med (2015)

Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer

Por Gainor, Justin F., Dardaei, Leila, Yoda, Satoshi, Friboulet, Luc, Leshchiner, Ignaty, Katayama, Ryohei, Dagogo-Jack, Ibiayi, Gadgeel, Shirish, Schultz, Katherine, Singh, Manrose, Chin, Emily, Parks, Melissa, Lee, Dana, DiCecca, Richard H., Lockerman, Elizabeth, Huynh, Tiffany, Logan, Jennifer, Ritterhouse, Lauren L., Le, Long P., Muniappan, Ashok, Digumarthy, Subba, Channick, Colleen, Keyes, Colleen, Getz, Gad, Dias-Santagata, Dora, Heist, Rebecca S., Lennerz, Jochen, Sequist, Lecia V., Benes, Cyril H., Iafrate, A. John, Mino-Kenudson, Mari, Engelman, Jeffrey A., Shaw, Alice T.
Publicado no Cancer Discov (2016)

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge

Por Brownstein, Catherine A, Beggs, Alan H, Homer, Nils, Merriman, Barry, Yu, Timothy W, Flannery, Katherine C, DeChene, Elizabeth T, Towne, Meghan C, Savage, Sarah K, Price, Emily N, Holm, Ingrid A, Luquette, Lovelace J, Lyon, Elaine, Majzoub, Joseph, Neupert, Peter, McCallie Jr, David, Szolovits, Peter, Willard, Huntington F, Mendelsohn, Nancy J, Temme, Renee, Finkel, Richard S, Yum, Sabrina W, Medne, Livija, Sunyaev, Shamil R, Adzhubey, Ivan, Cassa, Christopher A, de Bakker, Paul IW, Duzkale, Hatice, Dworzyński, Piotr, Fairbrother, William, Francioli, Laurent, Funke, Birgit H, Giovanni, Monica A, Handsaker, Robert E, Lage, Kasper, Lebo, Matthew S, Lek, Monkol, Leshchiner, Ignaty, MacArthur, Daniel G, McLaughlin, Heather M, Murray, Michael F, Pers, Tune H, Polak, Paz P, Raychaudhuri, Soumya, Rehm, Heidi L, Soemedi, Rachel, Stitziel, Nathan O, Vestecka, Sara, Supper, Jochen, Gugenmus, Claudia, Klocke, Bernward, Hahn, Alexander, Schubach, Max, Menzel, Mortiz, Biskup, Saskia, Freisinger, Peter, Deng, Mario, Braun, Martin, Perner, Sven, Smith, Richard JH, Andorf, Janeen L, Huang, Jian, Ryckman, Kelli, Sheffield, Val C, Stone, Edwin M, Bair, Thomas, Black-Ziegelbein, E Ann, Braun, Terry A, Darbro, Benjamin, DeLuca, Adam P, Kolbe, Diana L, Scheetz, Todd E, Shearer, Aiden E, Sompallae, Rama, Wang, Kai, Bassuk, Alexander G, Edens, Erik, Mathews, Katherine, Moore, Steven A, Shchelochkov, Oleg A, Trapane, Pamela, Bossler, Aaron, Campbell, Colleen A, Heusel, Jonathan W, Kwitek, Anne, Maga, Tara, Panzer, Karin, Wassink, Thomas, Van Daele, Douglas, Azaiez, Hela, Booth, Kevin, Meyer, Nic, Segal, Michael M, Williams, Marc S, Tromp, Gerard, White, Peter, Corsmeier, Donald, Fitzgerald-Butt, Sara, Herman, Gail, Lamb-Thrush, Devon, McBride, Kim L, Newsom, David, Pierson, Christopher R, Rakowsky, Alexander T, Maver, Aleš, Lovrečić, Luca, Palandačić, Anja, Peterlin, Borut, Torkamani, Ali, Wedell, Anna, Huss, Mikael, Alexeyenko, Andrey, Lindvall, Jessica M, Magnusson, Måns, Nilsson, Daniel, Stranneheim, Henrik, Taylan, Fulya, Gilissen, Christian, Hoischen, Alexander, van Bon, Bregje, Yntema, Helger, Nelen, Marcel, Zhang, Weidong, Sager, Jason, Zhang, Lu, Blair, Kathryn, Kural, Deniz, Cariaso, Michael, Lennon, Greg G, Javed, Asif, Agrawal, Saloni, Ng, Pauline C, Sandhu, Komal S, Krishna, Shuba, Veeramachaneni, Vamsi, Isakov, Ofer, Halperin, Eran, Friedman, Eitan, Shomron, Noam, Glusman, Gustavo, Roach, Jared C, Caballero, Juan, Cox, Hannah C, Mauldin, Denise, Ament, Seth A, Rowen, Lee, Richards, Daniel R, Lucas, F Anthony San, Gonzalez-Garay, Manuel L, Caskey, C Thomas, Bai, Yu, Huang, Ying, Fang, Fang, Zhang, Yan, Wang, Zhengyuan, Barrera, Jorge, Garcia-Lobo, Juan M, González-Lamuño, Domingo, Llorca, Javier, Rodriguez, Maria C, Varela, Ignacio, Reese, Martin G, De La Vega, Francisco M, Kiruluta, Edward, Cargill, Michele, Hart, Reece K, Sorenson, Jon M, Lyon, Gholson J, Stevenson, David A, Bray, Bruce E, Moore, Barry M, Eilbeck, Karen, Yandell, Mark, Zhao, Hongyu, Hou, Lin, Chen, Xiaowei, Yan, Xiting, Chen, Mengjie, Li, Cong, Yang, Can, Gunel, Murat, Li, Peining, Kong, Yong, Alexander, Austin C, Albertyn, Zayed I, Boycott, Kym M, Bulman, Dennis E, Gordon, Paul MK, Innes, A Micheil, Knoppers, Bartha M, Majewski, Jacek, Marshall, Christian R, Parboosingh, Jillian S, Sawyer, Sarah L, Samuels, Mark E, Schwartzentruber, Jeremy, Kohane, Isaac S, Margulies, David M
Publicado em 2014