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Comprehensive assessment of cancer missense mutation clustering in protein structures
Large-scale tumor sequencing projects enabled the identification of many new cancer gene candidates through computational approaches. Here, we describe a general method to detect cancer genes based on significant 3D clustering of mutations relative to the structure of the encoded protein products. T...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4603469/ https://ncbi.nlm.nih.gov/pubmed/26392535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516373112 |
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