Comprehensive assessment of cancer missense mutation clustering in protein structures

Large-scale tumor sequencing projects enabled the identification of many new cancer gene candidates through computational approaches. Here, we describe a general method to detect cancer genes based on significant 3D clustering of mutations relative to the structure of the encoded protein products. T...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Kamburov, Atanas, Lawrence, Michael S., Polak, Paz, Leshchiner, Ignaty, Lage, Kasper, Golub, Todd R., Lander, Eric S., Getz, Gad
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603469/
https://ncbi.nlm.nih.gov/pubmed/26392535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516373112
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