HER2 missense mutations have distinct effects on oncogenic signaling and migration

Recurrent human epidermal growth factor receptor 2 (HER2) missense mutations have been reported in human cancers. These mutations occur primarily in the absence of HER2 gene amplification such that most HER2-mutant tumors are classified as “negative” by FISH or immunohistochemistry assays. It remain...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zabransky, Daniel J., Yankaskas, Christopher L., Cochran, Rory L., Wong, Hong Yuen, Croessmann, Sarah, Chu, David, Kavuri, Shyam M., Red Brewer, Monica, Rosen, D. Marc, Dalton, W. Brian, Cimino-Mathews, Ashley, Cravero, Karen, Button, Berry, Kyker-Snowman, Kelly, Cidado, Justin, Erlanger, Bracha, Parsons, Heather A., Manto, Kristen M., Bose, Ron, Lauring, Josh, Arteaga, Carlos L., Konstantopoulos, Konstantinos, Park, Ben Ho
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653184/
https://ncbi.nlm.nih.gov/pubmed/26508629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516853112
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